In line with the Integral Healthcare Agreement (IZA), the Coalition for Lifestyle in Healthcare (Coalitie Leefstijl in de Zorg) focuses on the implementation of lifestyle in curative care. The Research team of the Coalition, which identified the knowledge questions and is initiating sustainable knowledge and infrastructure, is issuing this guide to support researchers, policymakers, funders, patient organisations and healthcare professionals in choosing the optimal method for evaluating the effectiveness of a lifestyle intervention in curative healthcare. Many different evaluation methods exist, each with their own possibilities and limitations. Such a broad palette is desirable because of the diversity of lifestyle interventions and the situations in which they are deployed. For each lifestyle intervention, it is necessary to consider which research design, analysis method and outcome measures are best suited for evaluating the effectiveness of a lifestyle intervention.